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WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation

✍ Scribed by Inés M Antón; Miguel A de la Fuente; Tasha N Sims; Sheryl Freeman; Narayanaswamy Ramesh; John H Hartwig; Michael L Dustin; Raif S Geha


Book ID
117723179
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
837 KB
Volume
16
Category
Article
ISSN
1074-7613

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta