Windowed stochastic proton decoupling for in vivo 13C magnetic resonance spectroscopy with reduced RF power deposition

✍ Scribed by Yun Xiang; Jun Shen

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 156 KB
• Volume: 34
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.22667

✦ Synopsis

Abstract

Purpose:

To propose a strategy for reducing radiofrequency (RF) power deposition by stochastic proton decoupling based on Rayleigh's theorem.

Materials and Methods:

Rayleigh's theorem was used to remove frequency components of stochastic decoupling over the 3.90–6.83 ppm range. [2‐^13^C] or [2,5‐^13^C~2~]glucose was infused intravenously to anesthetized rats. ^13^C labeling of brain metabolites was detected in the carboxylic/amide spectral region at 11.7 T using either the original stochastic decoupling method developed by Ernst or the proposed windowed stochastic decoupling method.

Results:

By restricting frequency components of stochastic decoupling to 1.91–3.90 ppm and 6.83–7.60 ppm spectral regions decoupling power deposition was reduced by ≈50%. The proposed windowed stochastic decoupling scheme is experimentally demonstrated for in vivo ^13^C MRS of rat brain at 11.7 T.

Conclusion:

The large reduction in decoupling power deposition makes it feasible to perform stochastic proton decoupling at very high magnetic fields for human brain ^13^C MRS studies. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.