Wilms' tumor—An interdisciplinary treatment program with and without dactinomycin

✍ Scribed by Lawrence W. Margolis; W. Byron Smith; William M. Wara; Joseph H. Kushner; Alfred A. Delorimier

• Book ID: 101322672
• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 422 KB
• Volume: 32
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197309)32:3<618::aid-cncr2820320314>3.0.co;2-6

✦ Synopsis

From 1945 through 1970, 61 patients with Wilms' tumor were analyzed for the treatment of primary tumor or metastatic lesions and for the development of metastases. Between 1945 a n d 1962, 21 patients were treated by nephrectomy a n d radiation therapy to the tumor beds; 10 of these (48%) remain well. Since 1962, dactinomycin has been added t o the treatment program of 40 patients. Twenty-two of these patients were treated entirely a t UCSF; 18 (82%) have no evidence of disease after 2 years or more. Eighteen cases were referred after initial treatment elsewhere; seven (39%) remain free of disease for the 2-year a t risk period. Maintenance courses of dactinomycin resulted in a marked decrease in the subsequent incidence of pulmonary metastases. I t