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Wilms' tumor 1 (WT1) gene in hematopoiesis: a surrogate marker of cell proliferation as a possible mechanism of action?

✍ Scribed by Olszewski, M.; Huang, W.; Chou, P.M.; Duerst, R.; Kletzel, M.

Book ID: 123420771
Publisher: Informa plc
Year: 2005
Tongue: English
Weight: 205 KB
Volume: 7
Category: Article
ISSN: 1465-3249
DOI: 10.1016/S1465-3249(05)70789-1

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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis