✦ LIBER ✦
Widespread expression of olfactory cyclic nucleotide-gated channel genes in rat brain: Implications for neuronal signalling
✍ Scribed by Paul A. Kingston; Frank Zufall; Colin J. Barnstable
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 777 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
✦ Synopsis
The cyclic nucleotides cAMP and cGMP are important intracellular messengers involved in a wide variety of signal transduction events in the nervous system. It has been proposed that cAMP/cGMP elicit some of their effects through direct gating of a novel class of Ca 2ϩ -permeable ion channels that are termed cyclic nucleotidegated (CNG) channels. Previous studies have identified the expression of a gene encoding one major CNG channel subtype, the olfactory receptor neuron ␣ subunit, in the brain [