Whole-arm t(1;16) and i(1q) as sole anomalies identify gain of 1 q as a primary chromosomal abnormality in breast cancer
✍ Scribed by Nikos Pandis; Dr. Sverre Heim; Georgia Bardi; Ingrid Idvall; Nils Mandahl; Felix Mitelman
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 373 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Cytogenetic analysis of four ductal breast carcinomas revealed net gain of I q in all tumors. In the first tumor, the only change was that one chromosome 16 was replaced by a derivative chromosome consisting of I6p and Iq. The same unbalanced whole-arm translocation was also found in the second tumor, as the only aberration in one of four abnormal clones. In the last two cases, which also were characterized by cytogenetically unrelated clones, an extra i( I q) was present in one clone in both tumors as the sole aberration. Our findings suggest that gain of I q is a primary chromosomal abnormality in breast carcinomas, in the sense that it is an early event that precedes the acquisition of more complex changes. Genes Chrorn Cancer Case 4
Histopathologic examination of a 2.8 x 2.4 cm breast tumor in a 61-year-old woman revealed a grade 111 ductal carcinoma. There were no lymph node or distant metastases.