White matter inhibitors in CNS axon regeneration failure
β Scribed by Fang Xie; Binhai Zheng
- Book ID
- 116459184
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 377 KB
- Volume
- 209
- Category
- Article
- ISSN
- 0014-4886
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Anamniote animals, such as fish and amphibians, are able to regenerate damaged CNS nerves following injury, but regeneration in the mammalian CNS tracts, such as the optic nerve, does not occur. However, severed adult mammalian retinal axons can regenerate into peripheral nerve segments grafted into
## Abstract Axon regeneration is arrested in the injured central nervous system (CNS) by axon growthβinhibitory ligands expressed in oligodendrocytes/myelin, NG2βglia, and reactive astrocytes in the lesion and degenerating tracts, and by fibroblasts in scar tissue. Growth cone receptors (Rc) bind i