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White matter hyperintensities in healthy older adults: A longitudinal study

โœ Scribed by Marcy A. Wohl; C. Mark Mehringer; Ira M. Lesser; Kyle B. Boone; Bruce L. Miller

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
495 KB
Volume
9
Category
Article
ISSN
0885-6230

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โœฆ Synopsis

A 3-year longitudinal study was conducted using magnetic resonance imaging (MRI) to determine the progression of white matter hyperintensities (WMH) and ventricle-to-brain ratio (VBR) in 16 healthy older adults. We found that, as a group, the subjects' WMH showed little progression over a 3-year period, but their VBR significantly increased during that same period of time. This increase occurred in healthy older adults who did not develop serious medical problems during the course of the 3-year study. In two of the subjects, with the largest increases in both WMH and VBR, there was a change in their heahh status.

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## Objective: This study examined whether mri evidence of cerebrovascular disease in the form of white matter hyperintensities (wmh) was associated with decreased implicit sequence learning performance in a high-functioning group of normal elderly volunteers. ## Method: One hundred and eight comm