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Whipple's disease with muscle impairment

✍ Scribed by Marie Puget; Jean Iwaz; Anne Tristan; Nathalie Streichenberger

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 217 KB
Volume: 34
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.20650

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✦ Synopsis

Abstract

A 67‐year‐old man presented with myalgia, muscle atrophy, and a history of seronegative polyarthritis. Blood tests showed inflammation but no hematologic or immunologic abnormalities. Muscle biopsy revealed no vasculitis or myositis but Tropheryma whipplei was detected by polymerase chain reaction in muscle, blood, and duodenum specimens; this was confirmed by immunohistochemistry. Ceftriaxone led to clinical improvement. Although rare, Whipple's disease should be considered in the differential diagnosis of diffuse myopathy. Muscle Nerve, 2006

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