The metabolic error involved in idiopathic hemochromatosis, as well as the underlying genetic defect remain unknown. It has, however, been recently shown that this genetic lesion occurs at a locus linked to the major histocompatibility complex, probably close to the HLA-A locus, and that the disease
Where does the gene for hemochromatosis lie in relation to HLA-A?
โ Scribed by Elizabeth C. Jazwinska; June W. Halliday; Lawrie W. Powell
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 266 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
โฆ Synopsis
Hereditary Hemochromatosis (HFE) is one of the most common inherited disorders with an estimated frequency of homozygous patients of 0.002-0.0046. The disease is characterized by increased intestinal iron absorption and progressive iron overload. Affected subjects show clinical symptoms of parenchymal organ damage after the third-fourth decade of life and have a 200-fold increased risk of developing hepatocellular HOLD THAT NEEDLE: OCTREOTIDE FOR ACUTE VARICEAL HEMORRHAGE
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