𝔖 Bobbio Scriptorium
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When does rheumatoid disease start?

✍ Scribed by K. Aho; T. Palosuo; V. Raunio; P. Puska; A. Aromaa; J. T. Salonen

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
449 KB
Volume
28
Category
Article
ISSN
0004-3591

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✦ Synopsis

START?

T. SALONEN Stored serum specimens collected in connection with a community-oriented epidemiologic study were available from 30 subjects who later developed seropositive rheumatoid arthritis. In 9 of these pre-rheumatoid specimens, the Rose-Waaler test result was positive, and in 16, the latex fixation test was positive. Two-thirds of the samples were positive when the interval between taking the blood specimen and onset of the disease was <4 years, and one-third were positive when the interval was 2 4 years. The occurrence of rheumatoid factor preceded the onset of clinical disease more often in males than in females.

Recent discussion on the pathogenesis of rheumatoid arthritis (RA) has focused on the relationships between host genetic factors, immunologically-mediated tissue injury, and an inciting agent (1).

The main hurnoral feature seen in RA is rheumatoid factor (RF) with autologous IgG (2,3). The From the

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