When does Parkinson's disease begin?
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Carles Gaig; Eduardo Tolosa
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Article
📅
2009
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John Wiley and Sons
🌐
English
⚖ 95 KB
## Abstract Pathological and neuroimaging studies have shown that in Parkinson's disease (PD) there is a “subclinical” or “premotor” period during which dopaminergic neurons in the substantia nigra (SN) degenerate but typical motor symptoms have not yet developed. Post‐mortem studies based on nigra