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When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd–DTPA Derivative Decreases Relaxivity

✍ Scribed by Peter Caravan; John C. Amedio Jr.; Stephen U. Dunham; Matthew T. Greenfield; Normand J. Cloutier; Sarah A. McDermid; Marga Spiller; Stephan G. Zech; Richard J. Looby; Arnold M. Raitsimring; Thomas J. McMurry; Randall B. Lauffer

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 177 KB
Volume: 11
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200500338

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**MRI contrast agents** act by relaxing water protons. When an acetate group on the MRI angiography contrast agent MS‐325 is replaced with a methyl group, it opens up a coordination site for a second water ligand. The additional water is expected to improve the relaxivity of the new complex, and thi