✦ LIBER ✦
What the papers say: Keeping it in the family: How T cells make antigen receptors
✍ Scribed by Alan Tunnacliffe
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 601 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The last year has unveiled extensive information on the T-cell antigen receptor genes. For both the a-andp-chains of this molecule, it is clear that an expressed gene is compiled from several coding sequences dispersed along the chromosome. During T-cell development, recombination events occur which create a single transcription unit from these dispersed elements. Such gene organization shows that the T-cell receptor has close evolutionary links with immunoglobulins. Both types of molecule use the same genetic mechanisms to create the diversity necessary for antigen recognition.