What is the role of bone-matrix and bone-marrow released in soft-tissue injury following fractures in the induction of systemic inflammation and remote organ damage?

Role of hemorrhage in the induction of s

Role of hemorrhage in the induction of systemic inflammation and remote organ damage: Analysis of combined pseudo-fracture and hemorrhagic shock

✍ Roman Pfeifer; Philipp Kobbe; Sophie S. Darwiche; Timothy R. Billiar; Hans-Chris 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 100 KB

## Abstract This study was performed to analyze the role of hemorrhage‐induced hypotension in the induction of systemic inflammation and remote organ dysfunction. Male C57/BL6 mice (6‐ to 10‐week old and 20–30 g) were used. Animals were either subjected to pseudo‐fracture [PF; standardized soft‐tis