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What is the best initial treatment and maintenance therapy for distal ulcerative colitis?

โœ Scribed by Dr. Massimo Campieri

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
167 KB
Volume
2
Category
Article
ISSN
1078-0998

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Thiopurine maintenance therapy for ulcer
Thiopurine maintenance therapy for ulcerative colitis: The clinical significance of monitoring 6-thioguanine nucleotide
โœ Hiroyuki Hanai; Takayuki Iida; Ken Takeuchi; Osamu Arai; Fumitoshi Watanabe; Jin ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 270 KB

Background: 6-Mercaptopurine (6-MP) is an effective maintenance medication in patients with ulcerative colitis (UC), but toxic effects like myelosuppression limit its clinical benefit. In the blood, 6-thioguanine (6-TGN) is formed from 6-MP and mediates the therapeutic efficacy and most of the toxic