✦ LIBER ✦

What can Drosophila tell us about serpins, thrombosis and dementia?

✍ Scribed by Robin Carrell; Javier Corral

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 228 KB
Volume: 26
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.10407

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The validity of the fruit‐fly as a model of human disease has been confirmed in a striking way by Green and colleagues.1 They show that the mutations causing a necrotic disease phenotype in Drosophila, precisely mirror those resulting in a group of well‐studied but perplexing diseases in the human. These diseases, ranging from thrombosis to dementia, arise from mutations causing a conformational instability of serpin protease inhibitors. The findings provide clues as to the unusual severity and variable onset of such conformational diseases and demonstrate the potential of Drosophila as a model for their future study. BioEssays 26:1–5, 2004. © 2003 Wiley Periodicals, Inc.

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