What can be done to prevent graft versus host disease?

✍ Scribed by Herman Waldmann; Stephen Cobbold; Geoffrey Hale

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 993 KB
• Volume: 6
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(94)90084-1

✦ Synopsis

Graft versus host disease presents a major obstacle to the widespread application of allogeneic bone marrow transplantation despite improvements in drug prophylaxis. Although animal models are providing an understanding of the biology of the process, opportunities for exploitation of that knowledge for therapeutic purposes are still limited. One way to overcome this impasse is to build on the positive benefits of T-cell purging of marrow, by combining it with intelligent correction of the known negative effects.