Ring flexibility within tricyclic antide
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Marco G. Casarotto; David J. Craik
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Article
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2001
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John Wiley and Sons
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English
β 203 KB
The internal Β―exibility of the central seven-membered ring of a series of tricyclic antidepressant drugs (TCAs), imipramine {1}, amitriptyline{2}, doxepin {3}, and dothiepin {4}, has been investigated by 1 H and 13 C nuclear magnetic (NMR) techniques. Two dynamic processes were examined: ring invers