✦ LIBER ✦

What are the molecular mechanisms of neural tube defects?

✍ Scribed by Jonathan Corcoran

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 42 KB
Volume: 20
Category: Article
ISSN: 0265-9247
DOI: 10.1002/(sici)1521-1878(199801)20:1<6::aid-bies3>3.0.co;2-t

No coin nor oath required. For personal study only.

✦ Synopsis

Neural tube defects (NTDs) are some of the most common human malformations. The vast majority of NTDs can be prevented by the administration of folic acid; however, to date there has been no effective treatment of folic acid-resistant NTDs. A recent paper 1 has confirmed an earlier report 2 that the administration of inositol to the curly tail mutant mouse, which is a model of folate-resistant NTDs, can cure such defects. The molecular pathway by which this is achieved is thought to occur by the up-regulation of the retinoic acid receptor ␤ in the underlying hindgut endoderm, correcting a proliferation defect. However, alternative explanations also may account for NTDs.

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