✦ LIBER ✦

What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?

✍ Scribed by G. Fürstenberger; P. Krieg; K. Müller-Decker; A.J.R. Habenicht

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 309 KB
Volume: 119
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22153

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Substantial evidence supports a functional role for cyclooxygenase‐ and lipoxygenase‐catalyzed arachidonic and linoleic acid metabolism in cancer development. Genetic intervention studies firmly established cause‐effect relations for cyclooxygenase‐2, but cyclooxygenase‐1 may also be involved. In addition, pharmacologic cyclooxygenase inhibition was found to suppress carcinogenesis in both experimental mouse models and several cancers in humans. Arachidonic acid‐derived eicosanoid or linoleic acid‐derived hydro[peroxy]fatty acid signaling are likely to be involved impacting fundamental biologic phenomina as diverse as cell growth, cell survival, angiogenesis, cell invasion, metastatic potential and immunomodulation. However, long chain unsaturated fatty acid oxidation reactions indicate antipodal functions of distinct lipoxygenase isoforms in carcinogenesis, i.e., the 5‐ and platelet‐type 12‐lipoxygenase exhibit procarcinogenic activities, while 15‐lipoxygenase‐1 and 15‐lipoxygenase‐2 may suppress carcinogenesis. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Precursors of neurons, neuroglia, and ep

Precursors of neurons, neuroglia, and ependymal cells in the CNS: What are they? Where are they from? How do they get where they are going?

✍ D. Kent Morest; Jerry Silver 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB

## Abstract Neurons, neuroglia (astrocytes and oligodendrocytes), and ependymal cells are three distinct categories of neural cells in the central nervous system. In the mature brain and spinal cord, the classical histological criteria define these cells by their microscopic structure very well. Du

Residuals generation and management in s

Residuals generation and management in selected chemicl industries. How great is the realistic potential damage to the environment from industrial wastewaters, and what are we doing about it?

✍ Langer, Barry S. ;Feiler, Howard D. 📂 Article 📅 1982 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 915 KB

The state of business competitive intell

The state of business competitive intelligence in Australia: What Australian firms are doing to heep competitive. Chris Hall and Babette Bensoussan, 1996, Mindshifts, Level 2, North Tower, 1–5 Railway Street, Chatswood NSW 2067, Sydney, Australia. 100 pages; $100 U.S. (including postage)

✍ John McGonagle 📂 Article 📅 1996 🏛 John Wiley and Sons ⚖ 102 KB

Tractor seats and the tractor driver's p

Tractor seats and the tractor driver's postural requirements : In: Noise and Vibration in Agriculture and Forestry. Proceedings of the 8th Joint Ergonomics Symposium, Silsoe, 9–12 September 1985, Edited by D.J. Bottoms and R.M. Stayner, 1985, 12 pp

✍ R.T. Whyte; T.S. Barber 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 141 KB

Obreschkoff's theorem revisited: What co

Obreschkoff's theorem revisited: What convex sets are contained in the set of hyperbolic polynomials?: Journal of pure and applied algebra 81 (3) (1992) 269–278

✍ Jean Pierre Dedieu; R.J. Gregorac 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 86 KB

The greenhouse effect will heat things u

The greenhouse effect will heat things up for electric utilities: Electric utilities and environmental groups are among those taking stock, in response to evidence that the Earth's climate is changing. Answers on what to do may not come quickly, however.

✍ Kennedy P. Maize 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 449 KB