✦ LIBER ✦
West Nile Virus inactivation by the solvent/detergent steps of the second and third generation manufacturing processes for B-domain deleted recombinant factor VIII
✍ Scribed by J. J. Jakubik; S. M. Vicik; M. M. Tannatt; B. D. Kelley
- Book ID
- 104461665
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 210 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1351-8216
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✦ Synopsis
Summary.
West Nile Virus (WNV) was immediately and completely inactivated to below assay detection limits upon addition of solvent/detergent (S/D) to intermediate process pools of second and third generation B‐domain deleted recombinant Factor VIII (BDDrFVIII; ReFacto, Wyeth, Cambridge, MA, USA). We verify that the S/D step provides robust enveloped virus inactivation (>5 log~10~) and functions as a WNV barrier.