Well-Defined Air-Stable Palladium HASPO Complexes for Efficient Kumada–Corriu Cross-Couplings of (Hetero)Aryl or Alkenyl Tosylates

✍ Scribed by Prof. Dr. Lutz Ackermann; Dr. Anant R. Kapdi; Dipl.-Chem. Sabine Fenner; Dipl.-Chem. Christoph Kornhaaß; Dr. Carola Schulzke

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 386 KB
• Volume: 17
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.201002386

✦ Synopsis

Abstract

Palladium complexes of representative __h__etero__a__tom‐substituted __s__econdary __p__hosphine __o__xide (HASPO) preligands were synthesized and fully characterized, including X‐ray crystal structure analysis. Importantly, these well‐defined complexes served as highly efficient catalysts for Kumada–Corriu cross‐coupling reactions of aryl, alkenyl, and even heteroaryl tosylates. Particularly, an air‐stable catalyst derived from inexpensive PinP(O)H displayed a remarkably high catalytic efficacy, which resulted in cross‐couplings at low catalyst loadings under exceedingly mild reaction conditions with ample scope.