Weekly low-dose paclitaxel and carboplatin in the treatment of advanced or recurrent cervical and endometrial cancer
β Scribed by Angeles Alvarez Secord; Laura J. Havrilesky; Michael E. Carney; John T. Soper; Daniel L. Clarke-Pearson; Gustavo C. Rodriguez; Andrew Berchuck
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 210 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1341-9625
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## Abstract ## BACKGROUND: A randomized phase 2 study was performed to investigate the efficacy/toxicity of combining concomitant boost radiation and weekly carboplatin/paclitaxel with or without amifostine in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). ##
## Background: Topotecan is a new antineoplastic agent with a broad spectrum of activity. the purpose of this phase i trial was to define the maximum tolerated dose of topotecan when added to the widely used combination of paclitaxel and carboplatin. ## Methods: Patients with advanced cancer that