## Background: The purpose of this study was to determine the feasibility and efficacy of hyperfractionated accelerated radiotherapy (hfrcb) combined with simultaneous chemotherapy with weekly cisplatin (cddp) in locally advanced inoperable head and neck cancer. ## Methods: From august 1999 to de
Weekly Gemcitabine and Cisplatin in Combination With Radiotherapy in Patients With Locally Advanced Head-and-Neck Cancer: Phase I Study
β Scribed by Gustavo Arruda Viani; Sergio Luis Afonso; Vivian Cardoso Tavares; Lucas Godoi Bernardes da Silva; Eduardo Jose Stefano
- Book ID
- 118455553
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 93 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0360-3016
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## Abstract ## BACKGROUND: Both concomitant chemotherapy and altered fractionation radiotherapy (RT) have been shown to improve outcomes for patients with locoregionally advanced head and neck squamous cell carcinomas. However, both strategies also increase acute toxicity, and it is questionable w
## Abstract ## Background. In locally advanced head and neck cancer, concurrent chemoradiotherapy (CRT) with combined 5βfluorouracil (5βFU) and cisplatin has increased acute toxicities as well as survival. Onceβweekly chemotherapeutic administration schedule may reduce severe toxicities. Thus, we