When selecting the physical form of an active pharmaceutical substance, there is often a question of when a molecule's pKa renders it too low for salt formation and formulation into a product that will be sufficiently physically stable to provide adequate shelf life. In the paper, a graph is provide
Weak interactions: Potency for stabilization of molecule in solid state
✍ Scribed by Rashmi Dubey; Ashish Kumar Tewari; K. Ravikumar; B. Sridhar
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 232 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.601
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✦ Synopsis
Abstract
Weak interactions usually show a versatile property to stabilize the molecular conformation and crystal packing in solid state. Crystal packing and conformational property of the synthesized compound 1(3‐cyano‐4,6‐dimethyl nicotinonitril‐1‐yl)‐3‐(phalimido‐1‐yl)‐1‐thioxyethane (2) is stabilized by CH···O, CH···N, and CH···π interactions. J. Heterocyclic Chem., 00, 00 (2011).
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