Wavelength shifts in solid-state circular dichroism spectra: A possible explanation

Stereochemical Studies on Medicinal Agen

Stereochemical Studies on Medicinal Agents. 24 Correlation of the Solid-State Conformations of 4-Phenylpiperidine Analgetic With the Torsional Relationship Between the Phenyl Group and Piperidine Ring in Solution, a Circular Dichroism Study

✍ Jacques H. Poupaert; Philip S. Portoghese 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) ⚖ 198 KB 👁 2 views

## Abstract A CD study of 8 representatives of 4‐phenylpiperidine analgetics is presented to correlate their solid‐state conformations with their chiroptical properties in solution. In addition to the benzenoid ^1^L~b~ fingerprint, the studied compounds exhibit two waves: the former band around 230