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Water-suppressed volume-selected 1H NMR spectroscopy in viva: Application to study tumor metabolism

✍ Scribed by Luke J. Haseler; Graham J. Galloway; James Field; Michael G. Irving; David M. Doddrell

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
264 KB
Volume
5
Category
Article
ISSN
0740-3194

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✦ Synopsis

Volume selection using SPACE has been combined with water suppression techniques to provide high-resolution 1H NMR spectra from aqueous solutions. The technique developed was used to obtain spectra from a tumor growing on the hind leg of a rat. Water suppression factors of between 1000 and 2000 were achieved simultaneously with excellent volume selection.

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✍ F. Desmoulin; S. Confort-Gouny; S. Masson; M. Bernard; D. M. Doddrell; P. J. Coz 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB

## Abstract Metabolism of ^13^C‐enriched metabolites can be advantageously studied by reverse‐polarization transfer methods. In this work an improved reverse‐DEPT sequence has been applied for the first time on perfused organs in a 20‐mm probe. The metabolic fate of 99% enriched [ 2‐^13^C] acetate