Water Soluble Star-block Copolypeptides: Towards Biodegradable Nanocarriers for Versatile and Simultaneous Encapsulation

✍ Scribed by Wensheng Zhuang; Lihui Liao; Heru Chen; Jinzhi Wang; Ying Pan; Lumian Zhang; Daojun Liu

• Book ID: 102492617
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 220 KB
• Volume: 30
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200800807

✦ Synopsis

Abstract

The synthesis of water soluble star‐block copolypeptides and their encapsulation properties are described. The star‐block copolypeptides, obtained by ring‐opening polymerization of amino acid N‐carboxyanhydrides, consist of a PEI core, a hydrophobic polyphenylalanine or polyleucine inner shell, and a negatively charged polyglutamate outer shell. The encapsulation study showed that these water soluble, amphiphilic star‐block copolypeptides could simultaneously encapsulate versatile compounds ranging from hydrophobic to anionic and cationic hydrophilic guest molecules.

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