Water-Soluble Polysaccharide from Eleutherococcus senticosus Stems Attenuates Fulminant Hepatic Failure Induced by D-Galactosamine and Lipopolysaccharide in Mice

Selective blockade of mGlu5 metabotropic

Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and d-galactosamine in mice

✍ Cristiano R. Jesse; Ethel A. Wilhelm; Cristiani F. Bortolatto; Lucielli Savegnag 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

## Abstract This study was designed to investigate the influence of 2‐methyl‐6‐phenylethynyl pyridine hydrochloride (MPEP), an antagonist of metabotropic glutamate receptor subtype 5, in lipopolysaccharide (LPS) and d‐galactosamine (d‐GalN)‐induced fulminant hepatic failure in mice. Mice were given