Water-soluble polyamides as potential drug carriers. VIII. Poly(alkylene oxide)-grafted polyaspartamides bearing ethylenediamine side-group functions

✍ Scribed by Eberhard W. Neuse; Axel G. Perlwitz; Anna P. Barbosa

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 541 KB
• Volume: 54
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.1994.070540106

✦ Synopsis

In continuation of previous investigations of aspartamide-type polymers as drug carriers, polyaspartamides featuring hydrosolubilizing poly ( alkylene oxide ) side chains in addition to ethylenediamine side-group functions as potential drug-binding sites are synthesized from poly-D,L-succinimide by successive aminolytic ring-opening steps. Yields are in the range of 45-55%. Depending on selected feed ratios, the target polymers contain both the poly ( alkylene oxide ) and the ethylenediamine groups in systematically varied proportions. Compositions are determined microanalytically and from relative band intensities of the 'H-NMR spectra. The polymers dissolve smoothly and completely in aqueous media and thus fulfill the major design requirement of water solubility.