Water soluble complexes of chitosan-g-MPEG and hyaluronic acid

✍ Scribed by Jun Wu; Xuefen Wang; Jong Kahk Keum; Hongwen Zhou; Mikhail Gelfer; Carlos-Alberto Avila-Orta; Hui Pan; Weiliam Chen; Shu-Min Chiao; Benjamin S. Hsiao; Benjamin Chu

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 329 KB
• Volume: 80A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.30972

✦ Synopsis

Abstract

Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS‐g‐MPEG) and negatively charged hyaluronic acid (HA). CS‐g‐MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG‐aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS‐g‐MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS‐g‐MPEG solution. The highest viscosity was obtained when the charge ratio of CS‐g‐MPEG/HA was close to 1.0. Small‐angle X‐ray scattering measurements provided some insights into the lamellar structure of the CS‐g‐MPEG/HA complex. The CS‐g‐MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium). © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006