✦ LIBER ✦
Water solubilization of xanthene dyes by post-synthetic sulfonation in organic media
✍ Scribed by Anthony Romieu; Delphine Tavernier-Lohr; Stéphane Pellet-Rostaing; Marc Lemaire; Pierre-Yves Renard
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 379 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Highly water-soluble fluorescent fluorescein and rhodamine dyes were synthesized through amidification of their carboxylic acid functionality with original di-or tri-sulfonated amino linkers derived from taurine or a-sulfo-b-alanine. This post-synthetic derivatization was performed in organic media both to minimize the premature hydrolysis and to suppress the precipitation of the involved active ester of fluorophore, frequently encountered using standard Schotten-Baumann conditions.