## Abstract Investigators often study rats by μCT to investigate the pathogenesis and treatment of skeletal disorders in humans. However, μCT measurements provide information only on bone mineral content and not the solid matrix. CT scans are often carried out on cancellous bone, which contains a s
Water and Fat Suppressed Proton Projection MRI (WASPI)/micro CT measurements of bone mineralization
✍ Scribed by Haihui Cao; Jerome Ackerman; Kirsten Ecklund; Shaun Steigman; Melvin Glimcher; Yaotang Wu
- Book ID
- 116320856
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 48 KB
- Volume
- 43
- Category
- Article
- ISSN
- 8756-3282
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## Abstract ## Purpose: To demonstrate water‐ and fat‐suppressed proton projection MRI (WASPI) in a clinical scanner to visualize the solid bone matrix in animal and human subjects. ## Materials and Methods: Pig bone specimens and polymer pellets were used to optimize the WASPI method in terms o
## Abstract Water‐ and fat‐suppressed projection MR imaging (WASPI) utilizes the large difference between the proton __T__s of the solid organic matrix and the fluid constituents of bone to suppress the fluid signals while preserving solid matrix signals. The solid constituents include collagen and