Was wissen wir über den molekularen Mechanismus der Erregung von Lichtsinneszellen?
✍ Scribed by Hennig Stieve
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 884 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0028-1042
No coin nor oath required. For personal study only.
✦ Synopsis
The mechanism of transduction of the light stimulus into an electrical response signal is described for visual cells of vertebrates and invertebrates. Absorption of a photon by a rhodopsin molecule in the photosensory membrane of the visual cell leads to a delayed, relatively large single-photon-evoked response, the elementary excitatory response. The rhodopsin molecule starts an enzyme cascade via a G-protein. This leads to a considerably amplified decrease (vertebrates), or increase (invertebrates) of a large number of intracellular messenger molecules. Binding of these messenger molecules causes the opening of the sodium-preferring ion channels in the plasma membrane. Our present knowledge of the molecular mechanisms involved is described.
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