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Warfarin inhibition of hepatic vitamin K epoxide reductase activity in warfarin-susceptible and -resistant house mice (Mus domesticus)

โœ Scribed by A.D. MacNicoll; R.H. Dean


Book ID
119027979
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
469 KB
Volume
44
Category
Article
ISSN
0048-3575

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Vitamin K epoxide reductase (VKOR) activity in liver microsomes from a susceptible and a genetically warfarin-resistant strain of mice (Mus Musculus domesticus) was analyzed to determine the mechanism of resistance to this 4-hydroxycoumarin derivative. Kinetic parameters for VKOR were calculated for