Wanted: subcellular localization of proteins based on sequence
β Scribed by Frank Eisenhaber; Peer Bork
- Book ID
- 114323295
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 144 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0962-8924
No coin nor oath required. For personal study only.
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Prediction of the cellular location of a protein plays an important role in inferring the function of the protein. Feature extraction is a critical part in prediction systems, requiring raw sequence data to be transformed into appropriate numerical feature vectors while minimizing information loss.
Protein p21(Cip1/Waf1) is a cyclin-dependent kinase inhibitor, which is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. Based on the localization, p21(Cip1/Waf1) protein executes various functions in the cell. In the nucleus p21(Cip1/Waf1) bi