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Waiting to Inhale: HIF-1 Modulates Aerobic Respiration

✍ Scribed by Adam T. Boutin; Randall S. Johnson

Book ID: 116353443
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 163 KB
Volume: 129
Category: Article
ISSN: 0092-8674
DOI: 10.1016/j.cell.2007.03.031

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## Abstract Cancer cells are able to tolerate levels of O~2~ that are damaging or lethal to normal cells; we hypothesize that this tolerance is the result of biochemical plasticity which maintains cellular homeostasis of both energy levels and oxidation state. In order to examine this hypothesis, w