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Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium

✍ Scribed by Jioji Tabudravu; Linda A. Morris; J.Jantina Kettenes-van den Bosch; Marcel Jaspars

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 78 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01993-1

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✦ Synopsis

The isolation and structure determination of an unusual cyclic heptapeptide, wainunuamide, from a Fijian marine sponge, Stylotella aurantium, is reported. The peptide contains three proline residues and a histidine residue, which is rare in cyclic peptides and has only previously been reported in a cyclic peptide isolated from the cyanobacterium Oscillatoria agardhii, suggesting a possible source of the peptide. Wainunuamide is found to have weak cytotoxic activity.

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