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W1267 Thiopurine-Induced Peripheral T Cells Apoptosis and Drug Response in Patients With Crohn's Disease

✍ Scribed by Cossu, Andrea; Biancone, Livia; Pallone, Francesco; Boirivant, Monica


Book ID
122499975
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
184 KB
Volume
138
Category
Article
ISSN
0016-5085

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Peripheral regulatory T cells and serum
✍ Antonio Di Sabatino; Paolo Biancheri; Silvia Piconese; M. Manuela Rosado; Sandro πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 745 KB

Background: CD4 ΓΎ Foxp3 ΓΎ regulatory T cells (Treg) inhibit Tcell proliferation in vitro and are effective in suppressing colitis in mouse models. Tumor necrosis factor (TNF)-a, which is centrally involved in Crohn's disease (CD) pathogenesis, also impairs Treg function. Here we investigated the inf