W1155 IL-21 Receptor Signaling Enhances NK Cell Cytolytic Activity and Induces Proinflammatory Cytokine Production in Inflammatory Bowel Disease

Il-21 enhances NK cell activation and cy

Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease

✍ Zhanju Liu; Li Yang; Yi Cui; Xingpeng Wang; Chuanyong Guo; Zhigang Huang; Quanch 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 750 KB

Background: Interleukin-21 (IL-21) is involved in T and NK cell activation and effector response and promotes Th17 cell differentiation. Here we investigated IL-21 receptor (IL-21R) expression in inflamed mucosa of inflammatory bowel disease (IBD) and evaluated its role in the induction of NK cell c