✦ LIBER ✦

VUV photon-induced ionization/dissociation of antipyrine and propyphenazone: mass spectrometric and theoretical insights

✍ Scribed by Liulin Deng; Lidong Zhang; Huijun Guo; Liangyuan Jia; Yang Pan; Hao Yin; Fei Qi

Book ID: 102380093
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 174 KB
Volume: 45
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.1763

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two analgesic and anti‐inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time‐of‐flight mass spectrometer (EI‐TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway. Copyright © 2010 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Mass spectrometric analysis of additives

Mass spectrometric analysis of additives in polymer extracts by desorption chemical ionization and collisional induced dissociation with B/E linked scanning

✍ C.G. Juo; S.W. Chen; G.R. Her 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 704 KB

Electrospray ionization and collision-in

Electrospray ionization and collision-induced dissociation tandem mass spectrometric discrimination of polyphenolic glycosides: exact acylation site determination of the O-acylated monosaccharide residues

✍ Shang-Gao Liao; Li-Juan Zhang; Zhen Wang; Fa Sun; Yong-Jun Li; Ai-Min Wang; Yong 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 849 KB

A Mobile Mass Spectrometer for Comprehen

A Mobile Mass Spectrometer for Comprehensive On-Line Analysis of Trace and Bulk Components of Complex Gas Mixtures: Parallel Application of the Laser-Based Ionization Methods VUV Single- Photon Ionization, Resonant Multiphoton Ioniza- tion, and Laser-Induced Electron Impact Ionization

✍ Mühlberger, F.; Zimmermann, R.; Kettrup, A. 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 634 KB

Behaviour of salts of very strong proton

Behaviour of salts of very strong proton-sponge bases in the gas phase: Extended proximity effects and maintenance of the hydrogen bridge under soft ionization. An electron impact and liquid secondary ion mass spectrometric/collision-induced dissociation tandem mass spectrometric study

✍ Marina Rentzea; Fredy Kühn; Heinz A. Staab 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB

The liquid secondary ion mass spectrometry and electron impact ionization fragmentation pathways of 1,9bis(dimethylamino)-2,8-dimethoxy-dibenzofuran (l), a new proton-sponge base with increased steric compression (buttressing) and much higher basicity (pK, = 14.3), and of its monoprotonated (2) and