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VPA inhibits breast cancer cell migration by specifically targeting HDAC2 and down-regulating Survivin

✍ Scribed by Lei Zhang; Guiying Wang; Lin Wang; Chenlin Song; Ye Leng; Xinhua Wang; Jiuhong Kang


Book ID
106459738
Publisher
Springer
Year
2011
Tongue
English
Weight
500 KB
Volume
361
Category
Article
ISSN
0300-8177

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## Abstract 3,3′‐Diindolylmethane (DIM) is a known anti‐tumor agent against breast and other cancers; however, its exact mechanism of action remains unclear. The urokinase plasminogen activator (uPA) and its receptor (uPAR) system are involved in the degradation of basement membrane and extracellul