VP16-213 in combined modality treatment of small cell carcinoma of the lung
β Scribed by Newman, Steven B.; Bitran, Jacob D.; Golomb, Harvey M.; Hoffman, Philip C.; DeMeester, Tom R.; Raghavan, Vathsala
- Book ID
- 122369905
- Publisher
- Elsevier Science
- Year
- 1982
- Weight
- 411 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0277-5379
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π SIMILAR VOLUMES
Small cell lung cancer requires aggressive combination chemotherapy. The three active agents, doxorubicin (A) 45 mg/m2 i.v. day 1, cyclophosphamide (C) 1.0 mg/m2 i.v. day 1 and VP16-213 (E) 50 mg/m2/day i.v. days 1-5 were given together. The combination (ACE) was given every 21 days without chest ir
Twelve patients with small-cell anaplastic carcinoma of the lung were treated with vincristine 1 mg/m2 i.v. day 1, adriamycin 50 mg/M2 i.v. day 1, cyclophosphamide 1,000 mg/m2 i.v. day 1, and etoposide 80 mg/m2 i.v. day 2, 4, 6 given on an outpatient basis and repeated at 3-week intervals. As consol
Thirty-eight patients with small cell carcinoma of the bronchus resistant to initial chemotherapy with cyclophosphamide methotrexate and CCNU, were treated with VP16-213 alone in a dose of 120 mg/m2 i.v. on days 1, 3, and 5 every 3 weeks. Twelve patients died before three courses of treatment. In 26