𝔖 Bobbio Scriptorium
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VP-16, vincristine and procarbazine with radiation therapy for treatment of malignant brain tumors

✍ Scribed by Richard M. Hellman; John A. Calogero; Bruce M. Kaplan

Book ID
104652454
Publisher
Springer US
Year
1990
Tongue
English
Weight
274 KB
Volume
8
Category
Article
ISSN
0167-594X

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✦ Synopsis

Twelve patients aged 34 to 65 with malignant gliomas were treated with VP-16, Procarbazine, Vincristine and concurrent radiation therapy. There were 9 patients with glioblastoma multiforme and 3 with anaplastic astrocytoma. All patients had a subtotal resection or biopsy as the initial procedure. Six patients (1 anaplastic astrocytoma) have developed progressive disease. Mean time to tumor progression was 46 weeks. This combined modality treatment program was associated with reversible hematologic toxicity which was severe in 2 patients. These data compare favorably to data obtained from similar patients treated with radiation therapy and BCNU.

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Complications associated with intra-arterial BCNU administered in combination with vincristine and procarbazine for the treatment of malignant brain tumors
✍ Alfonso M Bremer; Enrique Kleriga; Tai Q Nguyen; Raymond Balsys; H Martin Northu πŸ“‚ Article πŸ“… 1984 πŸ› Springer US 🌐 English βš– 301 KB

We have used intra-arterial (i.a.) 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) either alone or as part of adjuvant chemotherapy in patients with malignant brain tumors over a 3 year period (1979-1982). The i.a. BCNU technique was used 111 times to infuse 134 arteries in 37 patients. These patients,