Laboratory experiments were conducted to determine the flow-induced vibration (FIV) response and fluidelastic stability threshold of a model heat exchanger tube bundle subjected to a cross-flow of refrigerant 11. The tube bundle consisted of a normal square array of 12 tubes with outer tube diameters of 7.11 mm and a pitch over diameter ratio of 1.485. The experiments were conducted in a flow-loop that was capable of generating single-and two-phase cross-flows over a variety of mass fluxes and void fractions. The primary intent of the research was to improve our understanding of the FIVs of heat exchanger tube arrays subjected to two-phase cross-flow. Of particular concern was the effect of array pattern geometry on fluidelastic instability. The experimental results are analysed and compared with existing data from the literature using various methods of parameter definition. Comparison of tube vibration response in liquid flow with previous results shows a similar occurrence of symmetric vortex shedding that validates the scale model approach in single-phase flow. It was found that the introduction of a small amount of bubbles in the flow disrupted the vortex shedding and thereby caused a significant reduction in streamwise vibration amplitude. The fluidelastic stability thresholds for the present array agree well with results from previous studies. Furthermore, a good collapse of the stability data from various investigations is obtained when the fluid density is defined using the slip model of Feenstra et al. and when an effective two-phase flow velocity is defined using the interfacial velocity model of Nakamura et al.