Voriconazole, an antifungal drug
✍ Scribed by Ravikumar, K. ;Sridhar, B. ;Prasad, K. Durga ;Bhujanga Rao, A. K. S.
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 245 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
C 16 H 14 F 3 N 5 O, (I), is a triazole antifungal medication used to treat serious fungal infections. The dihedral angle between the planes of the fluoropyrimidine and triazole rings is 32.0 (2) and that between the difluorophenyl and triazole rings is 47.7 (2) . In addition to the O-HÁ Á ÁN intramolecular hydrogen bond, C-HÁ Á ÁO and C-HÁ Á ÁN interactions contribute to the molecular arrangement in the crystal packing.
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The therapeutic effect of sustained intravitreal injectable voriconazole microspheres (VCZ-MS) on experimental endophthalmitis caused by Aspergillus fumigatus was investigated. VCZ-MS were prepared and evaluated. Vitrectomy was performed on rabbits after intravitreal inoculation of susceptible A. fu