von Hippel-Lindau Gene Status and Response to Vascular Endothelial Growth Factor Targeted Therapy for Metastatic Clear Cell Renal Cell Carcinoma
β Scribed by Choueiri, Toni K.; Vaziri, Susan A.J.; Jaeger, Erich; Elson, Paul; Wood, Laura; Bhalla, Ish Prasad; Small, Eric J.; Weinberg, Vivian; Sein, Nancy; Simko, Jeff; Golshayan, Ali-Reza; Sercia, Linda; Zhou, Ming; Waldman, Frederic M.; Rini, Brian I.; Bukowski, Ronald M.; Ganapathi, Ram
- Book ID
- 122470663
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2008
- Tongue
- English
- Weight
- 592 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0022-5347
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## Abstract ## BACKGROUND. Therapy targeted against the vascular endothelial growth factor (VEGF) pathway is a standard of care for patients with metastatic renal cell carcinoma (RCC). The identification of patients who are more likely to benefit from these agents is warranted. ## METHODS. In to
## Abstract ## BACKGROUND A high frequency of genetic alterations of the von HippelβLindau (__VHL)__ gene and overexpression of the vascular endothelial growth factor (__VEGF)__ gene have been observed independently in human sporadic renal cell carcinoma (RCCs), but to the authors' knowledge the a