## Abstract Von HippelβLindau (VHL) disease is an uncommon, autosomal dominant hereditary multitumor syndrome caused by germline alterations of the __VHL__ gene, which has been cloned recently and identified as a tumor suppressor gene. The major lesions in VHL disease include hemangioblastomas in t
β¦ LIBER β¦
Von-Hippel-Lindau-Gen-Mutationstypen
β Scribed by V.D. Luu; B. Fischer; A. von Teichman; G. Boysen; K. Mertz; P. Zimmermann; H. Moch; P. Schraml
- Publisher
- Springer
- Year
- 2008
- Tongue
- German
- Weight
- 400 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0172-8113
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von Hippel-Lindau (VHL) disease is an autosomal dominant familial cancer syndrome predisposing to the development of retinal and central nervous system haemangioblastomas, pheochromocytomas, renal and pancreatic cancer. In the course of a molecular analysis conducted to detect germline mutations of