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Von Hippel-Lindau disease: strategies in early detection (renal-, adrenal-, pancreatic masses)

✍ Scribed by F. J. Hes; M. A. M. Feldberg


Book ID
113034186
Publisher
Springer
Year
1999
Tongue
English
Weight
634 KB
Volume
9
Category
Article
ISSN
0938-7994

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## Abstract Deletions of 3p25, gains of chromosomes 7 and 10, and isochromosome 17q are known cytogenetic aberrations in sporadic renal cell carcinoma (RCC). In addition, a majority of RCCs have loss of heterozygosity (LOH) of the Von Hippel‐Lindau (__VHL__) gene located at chromosome band 3p25. Pa